The Muzzio lab focuses on understanding the cellular, molecular, and circuit mechanisms associated with learning and memory and navigation. The specific questions that the lab is currently investigating are the following: A) What are the representations, network changes, and neural circuits underlying the retrieval of recent and remote emotional memories? (B) How do changes in sleep patterns during the lifespan affect memory and cognition? C) What are the brain mechanisms of spatial reorientation and how are they influenced by experience? The Muzzio lab studies these topics by recording single neurons or performing calcium imaging in freely moving mice in combination with behavioral, genetic, chemogenetic, optogenetic, and computational tools. By using several levels of analysis, from single cell to systems-level approaches, the lab’s research program is able to provide a comprehensive understanding of how normal and abnormal learning and memory processes occur and how learning impacts navigation.